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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/30692/19
    3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione
    Research 2020 : January - March
    Nadine Uwabagira, Balladka Kunhana Sarojini

    The compound 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-\nthiazolidine-2,4-dione has been designed, synthesized, and screened for its in vitro antibreast\ncancer activity, using human breast adenocarcinoma cell lines (MCF-7) and in vitro anti-inflammatory\nactivity. By hemolysis assay, it showed that it has a nonhemolytic and nontoxic effect on human blood\ncell. The title compound 5, subjected to in vitro activities, showed that it is cytotoxic with an IC50 of\n42.30 microM and a good anti-inflammatory agent. The docking results against cyclin dependent kinase 2\n(CDK2) (PDB ID: 3QQK) gave insights on its inhibitory activity

    How to Cite this Article
    Attribution/ CC Compliant Citation: Uwabagira, Nadine, and Balladka Kunhana Sarojini. \"3-{[(2, 3-Dichlorophenyl)\namino] methyl}-5-(furan-2-ylmethylidene)-1, 3-thiazolidine-2, 4-dione.\" Molbank 2019.4 (2019): M1083.\nhttps://doi:10.3390/M1083\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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